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Parameters

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Requisites
Measures

Number of red blood cells in the blood

Identifies

Red blood cell disorders

Measures: Number of red blood cells in the blood

Identifies: Red blood cell disorders

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What is the maximum days the report can be obtained for the test

The maximum days the report can be obtained for the test PNH Confirmation Test Flaer Method is 7 days.

What are the prerequisites for the test PNH Confirmation Test Flaer Method

  • Patients must have a suspected diagnosis of paroxysmal nocturnal hemoglobinuria (PNH)
  • Prior to testing, patients must have a complete blood count (CBC) and flow cytometry analysis showing evidence of PNH clone
  • Patients must not have received any red blood cell transfusions within the past 4 weeks
  • Patients must not have received eculizumab therapy within the past 4 weeks

What are the measure values for the test PNH Confirmation Test Flaer Method

Measure Values
CD24 Deficient Granulocytes Positive or Negative
CD55 Deficient Red Cells Positive or Negative
CD59 Deficient Red Cells Positive or Negative

What does this test PNH Confirmation Test Flaer Method identify?

This test, the PNH Confirmation Test Flaer Method, identifies the presence of paroxysmal nocturnal hemoglobinuria (PNH) using the Fluorescent Aerolysin (Flaer) method. PNH is a rare acquired disorder characterized by the destruction of red blood cells, leading to symptoms such as hemolytic anemia, blood clots, and bone marrow failure. The Flaer method specifically detects the absence of glycosylphosphatidylinositol (GPI)-anchored proteins on the surface of blood cells, which is a hallmark of PNH. This test helps confirm a diagnosis of PNH and guide appropriate treatment decisions.

Why is this test PNH Confirmation Test Flaer Method taken?

The PNH Confirmation Test Flaer Method is taken to confirm a diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH). PNH is a rare and serious blood disorder characterized by the destruction of red blood cells, leading to symptoms such as dark urine, fatigue, and abdominal pain. The Flaer Method is a specific laboratory test that detects the absence of certain proteins on the surface of blood cells, which is a hallmark of PNH.

By confirming the presence of PNH through this test, healthcare providers can determine the appropriate treatment plan for the patient, which may include medications to help manage symptoms and prevent complications. Additionally, a confirmed diagnosis of PNH can also help guide ongoing monitoring and management of the condition to ensure the best possible outcomes for the patient.

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