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Number of red blood cells in the blood

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Red blood cell disorders

Measures: Number of red blood cells in the blood

Identifies: Red blood cell disorders

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What is the maximum days the report can be obtained for the test

Maximum Days for Obtaining the O6-Methylguanine Methyltransferase (MGMT) Promoter Test Report

The report for the O6-Methylguanine Methyltransferase (MGMT) Promoter Test can be obtained within 5-7 business days from the date of testing.

What are the prerequisites for the test O6-Methylguanine Methyltransferase (MGMT) Promoter Test

  • Specimen: Formalin-fixed, paraffin-embedded (FFPE) tissue block or slides
  • Minimum Tumor Content: at least 20% tumor cells
  • Storage: FFPE tissue blocks or slides should be stored at room temperature
  • Requisition Form: Complete and accurate requisition form with patient information, clinical history, and relevant test requested
  • Medical Necessity: Test must be ordered by a qualified healthcare provider for a valid medical reason

What are the measure values for the test O6-Methylguanine Methyltransferase (MGMT) Promoter Test

  • Normal: MGMT promoter methylation < 10%
  • Borderline: MGMT promoter methylation 10-20%
  • Abnormal: MGMT promoter methylation > 20%

What does this test O6-Methylguanine Methyltransferase (MGMT) Promoter Test identify?

This test identifies the methylation status of the O6-Methylguanine Methyltransferase (MGMT) promoter region. MGMT is a DNA repair enzyme that plays a crucial role in protecting cells from alkylating agents, such as chemotherapy drugs. Methylation of the MGMT promoter region can lead to gene silencing, resulting in decreased MGMT expression and reduced DNA repair capability. This test helps in predicting the response of cancer patients to alkylating chemotherapy drugs by determining the likelihood of MGMT promoter methylation.

Why is this test O6-Methylguanine Methyltransferase (MGMT) Promoter Test taken?

The O6-Methylguanine Methyltransferase (MGMT) Promoter Test is taken to determine the methylation status of the MGMT gene promoter. This test is often used to predict the response of certain cancers, particularly glioblastoma multiforme, to alkylating agents such as temozolomide.

The MGMT gene encodes a DNA repair enzyme that removes alkyl groups from the O6 position of guanine, preventing DNA damage. Methylation of the MGMT gene promoter silences its expression, leading to decreased repair of DNA damage caused by alkylating agents. Patients with MGMT promoter methylation are more likely to respond to alkylating agents and have better outcomes compared to those without methylation.

Therefore, the MGMT promoter test is important in guiding treatment decisions for patients with certain cancers, helping to personalize therapy and improve patient outcomes.

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