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Measures

Number of red blood cells in the blood

Identifies

Red blood cell disorders

Measures: Number of red blood cells in the blood

Identifies: Red blood cell disorders

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What is the maximum days the report can be obtained for the test

The maximum days for obtaining the report for the DPD (Dihydropyrimidine Dehydrogenase) Gene Mutation Test is typically 10-14 days.

What are the prerequisites for the test DPD (Dihydropyrimidine Dehydrogenase) Gene Mutation Test

  • Written consent from the patient
  • Referral from a healthcare provider
  • Medical history of the patient
  • Information about any medications currently being taken by the patient
  • Knowledge of any previous reactions to chemotherapy drugs

What are the measure values for the test DPD (Dihydropyrimidine Dehydrogenase) Gene Mutation Test

  • Test Name: Dihydropyrimidine Dehydrogenase (DPD) Gene Mutation Test
  • Measure Values:
    • Normal: Negative for DPD gene mutation
    • Abnormal: Positive for DPD gene mutation

What does this test DPD (Dihydropyrimidine Dehydrogenase) Gene Mutation Test identify?

DPD (Dihydropyrimidine Dehydrogenase) Gene Mutation Test

The DPD gene mutation test identifies mutations in the Dihydropyrimidine Dehydrogenase gene. DPD is an enzyme that plays a crucial role in the breakdown of certain medications, specifically fluoropyrimidines like 5-fluorouracil and capecitabine. Mutations in the DPD gene can lead to reduced or absent enzyme activity, resulting in poor drug metabolism and potentially severe side effects.

Individuals with DPD gene mutations may be at an increased risk of experiencing toxicities from fluoropyrimidine-based chemotherapy. Therefore, this test is important in guiding personalized treatment decisions for cancer patients to avoid adverse reactions and optimize treatment outcomes.

Why is this test DPD (Dihydropyrimidine Dehydrogenase) Gene Mutation Test taken?

The Dihydropyrimidine Dehydrogenase (DPD) Gene Mutation Test is taken to determine if an individual has genetic mutations that affect the functioning of the DPD enzyme. The DPD enzyme is responsible for breaking down certain medications, including 5-fluorouracil and capecitabine, which are commonly used in cancer treatment.

Individuals with DPD gene mutations may have reduced enzyme activity, leading to the accumulation of toxic levels of these medications in the body. This can result in severe side effects, such as diarrhea, nausea, vomiting, and even life-threatening complications.

By identifying DPD gene mutations before starting treatment with medications metabolized by this enzyme, healthcare providers can adjust the dosage or choose alternative medications to prevent adverse reactions. This test is particularly important for individuals with a family history of DPD deficiency or previous experience of adverse reactions to 5-fluorouracil or capecitabine.

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