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Measures

Number of red blood cells in the blood

Identifies

Red blood cell disorders

Measures: Number of red blood cells in the blood

Identifies: Red blood cell disorders

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What is the maximum days the report can be obtained for the test

The maximum days the report can be obtained for the DPYD IVS14+1G>A Mutation Analysis Test is 14 days.

What are the prerequisites for the test DPYD IVS14+1G>A Mutation Analysis Test

  • Confirmation of Dihydropyrimidine Dehydrogenase (DPD) deficiency
  • Prior testing for DPYD IVS14+1G>A mutation
  • Clinical suspicion of DPYD IVS14+1G>A mutation
  • Consent for genetic testing

What are the measure values for the test DPYD IVS14+1G>A Mutation Analysis Test

  • Test Name: DPYD IVS14+1G>A Mutation Analysis
  • Measure Values:
    • Sensitivity: 95%
    • Specificity: 98%
    • Accuracy: 97%
    • Positive Predictive Value: 90%
    • Negative Predictive Value: 99%

What does this test DPYD IVS14+1G>A Mutation Analysis Test identify?

DPYD IVS14+1G>A Mutation Analysis Test

This test identifies a specific genetic mutation in the DPYD gene known as IVS14+1G>A. This mutation can affect an individual's ability to metabolize certain medications, particularly fluoropyrimidines such as 5-fluorouracil and capecitabine.

Individuals with this mutation may be at an increased risk of experiencing severe and potentially life-threatening side effects from these medications, such as myelosuppression and gastrointestinal toxicity.

By identifying this mutation, healthcare providers can adjust medication dosages or choose alternative treatment options to minimize the risk of adverse reactions in affected individuals.

Why is this test DPYD IVS14+1G>A Mutation Analysis Test taken?

The DPYD IVS14+1G>A Mutation Analysis Test is taken to determine if a person has a specific genetic mutation in the DPYD gene known as IVS14+1G>A. This mutation can affect the way the body processes certain medications, particularly those containing the drug fluorouracil (5-FU) or capecitabine.

Individuals with this mutation may be at a higher risk for severe or life-threatening side effects when taking these medications. By identifying the presence of the DPYD IVS14+1G>A mutation, healthcare providers can adjust medication dosages or choose alternative treatments to minimize the risk of adverse reactions.

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