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Parameters

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Requisites
Measures

Number of red blood cells in the blood

Identifies

Red blood cell disorders

Measures: Number of red blood cells in the blood

Identifies: Red blood cell disorders

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What is the maximum days the report can be obtained for the test

The report for the Thiopurine Methyltransferase (TPMT) Genotyping Test can typically be obtained within 7-10 days after the test is conducted.

What are the prerequisites for the test Thiopurine Methyltransferase (TPMT) Genotyping Test

  • Age: None
  • Gender: None
  • Fasting: Not Required
  • Medications: None
  • Other Requirements: None

What are the measure values for the test Thiopurine Methyltransferase (TPMT) Genotyping Test

  • Test Name: Thiopurine Methyltransferase (TPMT) Genotyping Test
  • Measure Values:
    • Normal/Non-carrier: 25-35 units/g Hb
    • Heterozygous Carrier: 10-15 units/g Hb
    • Homozygous Carrier: <10 units/g Hb

What does this test Thiopurine Methyltransferase (TPMT) Genotyping Test identify?

The Thiopurine Methyltransferase (TPMT) Genotyping Test identifies genetic variations in the TPMT gene that can affect how an individual metabolizes thiopurine medications. These medications are commonly used to treat autoimmune diseases such as inflammatory bowel disease and leukemia.

Why is this test Thiopurine Methyltransferase (TPMT) Genotyping Test taken?

The Thiopurine Methyltransferase (TPMT) Genotyping Test is taken to determine an individual's TPMT enzyme activity levels. This test is important for patients who are prescribed thiopurine medications, such as azathioprine, 6-mercaptopurine, and thioguanine, for conditions like inflammatory bowel disease, autoimmune disorders, and leukemia.

TPMT enzyme helps in the metabolism of thiopurine medications in the body. Individuals with low TPMT enzyme activity are at risk of developing severe side effects, such as bone marrow suppression, liver toxicity, and pancreatitis, when taking thiopurine medications. On the other hand, individuals with high TPMT enzyme activity may not respond adequately to thiopurine medications.

By identifying an individual's TPMT genotype, healthcare providers can personalize the dosage of thiopurine medications to reduce the risk of adverse effects and maximize therapeutic benefits. This test is particularly important before starting thiopurine therapy to ensure the safety and efficacy of treatment.

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