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Reports Within:

Parameter Include:

Requisites
Measures

Number of red blood cells in the blood

Identifies

Red blood cell disorders

Measures: Number of red blood cells in the blood

Identifies: Red blood cell disorders

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What is the maximum days the report can be obtained for the test

The maximum days for obtaining the report for the ETV6-RUNX1 t(12;21) (p13;q22) Test By FISH is typically within 7-10 business days from the date of sample collection.

What are the prerequisites for the test ETV6-RUNX1 t(12;21) (p13;q22) Test By FISH

  • Specimen: Bone marrow aspirate or peripheral blood
  • Sample container: Green top sodium heparin tube
  • Specimen volume: Minimum 2 mL
  • Transport: Room temperature
  • Test schedule: Monday - Friday
  • Turnaround time: 5-7 days

What are the measure values for the test ETV6-RUNX1 t(12;21) (p13;q22) Test By FISH

Measure Values for ETV6-RUNX1 t(12;21) Test By FISH
Translocation: t(12;21)(p13;q22)

What does this test ETV6-RUNX1 t(12;21) (p13;q22) Test By FISH identify?

Test Name: ETV6-RUNX1 t(12;21) (p13;q22) Test By FISH

Identification: This test identifies the presence of the ETV6-RUNX1 fusion gene, which results from a translocation between chromosomes 12 and 21 at the specific breakpoints p13 and q22. This fusion gene is associated with a subtype of childhood acute lymphoblastic leukemia (ALL) known as pre-B-cell ALL.

Method: Fluorescence in situ hybridization (FISH) is used to detect the fusion gene by labeling specific DNA sequences with fluorescent probes. These probes bind to the target DNA regions on chromosomes 12 and 21, allowing for visualization under a fluorescent microscope.

Significance: The presence of the ETV6-RUNX1 fusion gene is a critical diagnostic marker for guiding treatment decisions in patients with pre-B-cell ALL. Identifying this genetic abnormality allows for targeted therapies and personalized treatment plans to improve patient outcomes.

Why is this test ETV6-RUNX1 t(12;21) (p13;q22) Test By FISH taken?

Reason for ETV6-RUNX1 t(12;21) (p13;q22) Test By FISH

Reason for Test:

The ETV6-RUNX1 t(12;21) translocation is a common genetic abnormality found in pediatric acute lymphoblastic leukemia (ALL). This test is performed using Fluorescence In Situ Hybridization (FISH) to detect this specific translocation.

Detail:

  • Diagnosis: The presence of ETV6-RUNX1 fusion gene is a diagnostic marker for B-cell precursor ALL.
  • Prognosis: Patients with ETV6-RUNX1 fusion gene generally have a good prognosis and respond well to treatment.
  • Monitoring: Monitoring the presence of the ETV6-RUNX1 fusion gene during and after treatment can help assess the effectiveness of therapy.

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